Patients with nephrotic syndrome how antihypertensive treatment

Patients with nephrotic syndrome how antihypertensive treatment of nephrotic syndrome, etc. Most of the patients concern, Shijiazhuang kidney disease hospital for a brief introduction in patients with nephrotic syndrome how antihypertensive treatment
About half of the nephrotic syndrome patients with mild hypertension, the more the swelling to subside or reduce the return to normal, so mild hypertension may from time to treatment. If blood pressure is above 21.3 / 13.3kPa and swelling after blood pressure returned to normal, should be taken to antihypertensive therapy, commonly used antihypertensive drugs and usage are as follows:
(1) angiotensin-converting enzyme inhibitors: The antihypertensive mechanism of this class of drugs, mainly through inhibition of angiotensin conversion enzyme activity, lower angiotensin Ⅱ, the relaxation of small arteries up to step-down purposes. Renal hypertension caused by kidney disease caused by the increase in renin secretion, this has a good antihypertensive effect, In addition, there are sure of renal function deterioration, reduce proteinuria and to reduce the role of glomerular sclerosis, Therefore, for clinical used.
① captopril: oral 1 25 ~ 50mg, 3 times a day.
② benzene Plymouth (Lotensin): oral administration of a sub-10mg daily, according to condition daily increased to 40mg.
(2) calcium antagonists: Most of the studies confirmed that this class of drugs in addition to the antihypertensive effect, and yet to delay the deterioration of renal function.
① nifedipine: oral 1 5 ~ 10mg, 2-3 times daily.
② amlodipine (Norvasc): 1 times a day, 5mg, daily maximum dose of 10mg, oral.
(3) p-blockers: This class of drugs by reducing cardiac output and buck, there are to reduce the role of the renin, renin-dependent hypertension has a good effect, without affecting the kidney blood flow and glomerular filtration rate.
① metoprolol: oral 1 50 ~ 200mg daily.
② Atenolol: oral 1 50 ~ 100mg daily.
(4) vasodilator drugs, hydralazine, prazosin hydrochloride, etc. can be selected, the former general daily 200mg, the latter in general daily 6 ~ 12mg.
(Doctor's orders: The patient must not be self-medication, the drugs must be selected under the guidance of the physician service)
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