Refractory Nephrotic Syndrome refers to a kind of Nephrotic Syndrome that can not remit by the full doses of hormones treatment lasting for more than 8~12 weeks. A long-term suffering of Refractory Nephrotic Syndrome can induce serious infections, Acute Renal Failure, Thromboembolism Syndrome and other fatal complications, and this disease will finally develop into Chronic Kidney Failure, thus threatening the patients' life.
Then, how should we to treat Refractory Nephrotic Syndrome?
When treating Refractory Nephrotic Syndrome, some influencing factors should be excluded first. And when the influencing factors are excluded, patients with Refractory Nephrotic Syndrome will become sensitive to hormones, or remit spontaneously. For example, if the using of hormones and cytotoxic drugs is non-standard, then it should be corrected. If Refractory Nephrotic Syndrome is caused by infections and other influencing factors, then many patients with Refractory Nephrotic Syndrome can be cured by such methods as removing the causes of the disease, eliminating the inflammatory focus and correcting the clotting mechanism. For example, there once were two patients with Refractory Nephrotic Syndrome who are of this kind: one case is by the treatment of large doses of prednisone for three months, there is no curative effect. And after doing an inspection, it is found that the patient has periodontal abscess. Therefore, when the ill teeth were removed, the patient with Refractory Nephrotic Syndrome remitted rapidly. The other case is that there is no curative effect either by the implosive therapy of large doses of hormones and cyclophosphamide for six months, but by a systemic body examination, the patient with Refractory Nephrotic Syndrome was suspected of being allergic to decoration materials. Therefore, when the patient moved out of the new house, his condition remitted spontaneously.
As the influencing factors are excluded, the following treatments can be taken into consideration:
1. Changing cytotoxic drugs into mycophenolate mofetil and cyclophosphamide for treating Refractory Nephrotic Syndrome.
2. Adopting methylprednisolone implosive therapy for treating Refractory Nephrotic Syndrome.
It is acknowledged that even the aforementioned treatments are adopted, not all patients with Refractory Nephrotic Syndrome can be treated effectively. There is still no curative effect in treating Nephrotic Syndrome of some of the pathological types(such as Mesangial Proliferative Glomerulonephritis).
As there is no curative effect, the aforementioned treatments should be stopped(the dose of hormone should be reduced gradually under the guidance of a doctor, and it can not be stopped suddenly when large doses of hormones are adpted.), so as to avoid serious drug side effects.
When the medicines are stopped to use, supporting treatment and symptomatic treatment should be strengthen, and traditional Chinese Medicine can be adopted.
Micro-Chinese Medicine Osmotherapy in our hospital can treat Refractory Nephrotic Syndrome effectively.
And more information about Nephrotic Syndrome

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