How Does Western Medicine Treat IgA Nephropathy?

It is true that the curative effect of Western medicine is quick. In the treatment of IgA kidney disease, many patients are eager to get recovery recovered and receive Western medicine treatment.
So, how does Western medicine treat IgA nephropathy? At present, the main measures used to treat IgA kidney disease by Western medicine are as follows:
I General treatment
For the gross hematuria patients who have had upper respiratory tract infection, they should be treated by with effective antibiotic. For the IgA nephropathy patients with high blood pressure, we should take active measures to control the high blood pressure to lest hemodynamics abnormality and vascular impairment which can aggravate the nephritis’ conditions. For those patients who suffer from repeated gross hematuria, tonsil resection operation can be considered. Some reports point out that 40% of IgA hematuria patients can remit after having their tonsils focus resected.
II Regulate immune response
Taking Prednisolone to treat IgA nephritis, there is a 40% remission rate of the disease; combing to use Dipyridamole, Cyclophosphamide and P:dilantin ( 5-6mg/kg per daydaily), the serum IgA level can be lowered; taking Cyclosporine A ( 5mg/kg per daydaily), then the protein level can be lowered.
III Remove the immune complex in the blood circulation
After removing the immune complex in the blood circulation and letting the IgA nephritis patients take bran-free food for 6 months to 4 year, the IgA in the blood can decline dramatically, the condition of urine protein and hematuria can also be improved. The usage of intal for 1.2g per daydaily can reduce the protein level.
IV Reduce the sedimentation of IgA at the mesangial area
Taking Daonil,200mg, 200mg dailyper day, for 4 months, C3, the alexin, increases and urine protein level decreases. The usage of icosapeptide pentanoate and fish oil for 1.6g daily per day can delay the deteriorations of renal functions offunctions of IgA nephropathy patients.
In the first two measures, clinical data show that treating patients only by with Western medicine can improve the conditions of protein, occult and blood pressure. However, it can only temporarily inhibit other complications, and when the patients come across colds, infections and other unfavorable factors, many other symptoms of the disease will appear again.
Among the 110 IgA nephrit patients who are receiving treatments in Shijiazhuang Kidney Disease Hospital, most of them are treated in with the above-mentioned traditional therapies at the early stage of the disease, but the repeated relapses trouble them. Yet, in Shijiazhuang Kidney Disease Hospital, after receiving combing treatment of Chinese and Western medicine with Micro-Chinese Medicine Osmotherapy, the tracking statistics show that 98% patients gain favorable curative effects and the illness usually don’t recur. The most important is that the Micro-Chinese osmotherapy can effect a fundamental and permanent cure. It can not only clear away the immune complex at the glomerular basement membrane, but also, at the same time, restore the damaged organization of kidney and renew the function of kidney.

New Treatment Method for Childhood Nephrotic Syndrome

At present, many children are suffering from Nephrotic Syndrome. Due to they are a special group, we need to pay much attention when choosing the treatment for them. The common problems worrying the parents are that: long-term oral medicine causing body change or short stature in the children; taking medicine for a long period, protein in urine is still there; the disease is controlled, but after a period, it comes again.

New Treatment Method for Childhood Nephrotic Syndrome

Why the commonly used medicines lead to side effects to the children and why Nephrotic Syndrome is easy to relapse?
In Western medicine treatment method, hormone and immunosuppression are commonly used to treat Childhood Nephrotic Syndrome. This treatment method has obvious therapeutic effect at the very beginning, especially, they can make patients relieve from clinical symptoms, like protein leakage and edema. While this therapy will inevitably cause side effects and influence the growth and development of intelligence and body of the children, because it will restrain the abnormal immune response as well as the normal immume response. Besides, the disease is easy to relapse when stop to use the medicine or reduce the dosage, as well as there is cold or infection.
The root cause of Nephrotic Syndrome is the damage to renal intrinsic cells (eithelial cells), thus losing their function of charge barrier, then protein will leak from blood to urine and there will be less protein in the blood; besides protein can help the blood soak up water from tissues, when not enough protein is left in the blood to soak up the water, the water then moves from the blood into body tissues, producing edema. Therefore, the key point to treat the disease is to repair the renal intrinsic cells (epithelial cells) and recover their function.
While, are there some treatment methods that can treat Childhood Nephrotic Syndrome from the root so as to reduce the pain of the children?
There are new methods for the Childhood Nephrotic Syndrome: Micro-Chinese Medicine Osmotherapy and Stem Cell Transplant aim to repair and recover the function of the renal intrinsic cells, thus achieving the purpose of treating Childhood Nephrotic Syndrome fundamentally.
Micro-Chinese Medicine Osmotherapy refers to that first, we make the effective Chinese medicine for kidney disease superfinely shattered, then the micronized Chinese medicine is permeated into kidney lesions through the skin on the back via kidney area with the help of effective penetrant and osmosis devices. Micro-Chinese Medicine can block the further damage to kidneys, repair the damaged but reversible kidney units, and rebuild the normal kidney structure. When receiving the treatment, it is just like the feeling of doing massage. It takes only 45 minutes every time. It is used externally after being refined so as to avoid the side effects of oral medicines and has a quick effect. After several days, symptoms like protein in urine, edema etc all can be relieved and controlled gradually.

How to Treat Refractory Nephrotic Syndrome?

Refractory Nephrotic Syndrome refers to a kind of Nephrotic Syndrome that can not remit by the full doses of hormones treatment lasting for more than 8~12 weeks. A long-term suffering of Refractory Nephrotic Syndrome can induce serious infections, Acute Renal Failure, Thromboembolism Syndrome and other fatal complications, and this disease will finally develop into Chronic Kidney Failure, thus threatening the patients' life.
 Then, how should we to treat Refractory Nephrotic Syndrome?

When treating Refractory Nephrotic Syndrome, some influencing factors should be excluded first. And when the influencing factors are excluded, patients with Refractory Nephrotic Syndrome will become sensitive to hormones, or remit spontaneously. For example, if the using of hormones and cytotoxic drugs is non-standard, then it should be corrected. If Refractory Nephrotic Syndrome is caused by infections and other influencing factors, then many patients with Refractory Nephrotic Syndrome can be cured by such methods as removing the causes of the disease, eliminating the inflammatory focus and correcting the clotting mechanism. For example, there once were two patients with Refractory Nephrotic Syndrome who are of this kind: one case is by the treatment of large doses of prednisone for three months, there is no curative effect. And after doing an inspection, it is found that the patient has periodontal abscess. Therefore, when the ill teeth were removed, the patient with Refractory Nephrotic Syndrome remitted rapidly. The other case is that there is no curative effect either by the implosive therapy of large doses of hormones and cyclophosphamide for six months, but by a systemic body examination, the patient with Refractory Nephrotic Syndrome was suspected of being allergic to decoration materials. Therefore, when the patient moved out of the new house, his condition remitted spontaneously.

As the influencing factors are excluded, the following treatments can be taken into consideration:

1. Changing cytotoxic drugs into mycophenolate mofetil and cyclophosphamide for treating Refractory Nephrotic Syndrome.

2. Adopting methylprednisolone implosive therapy for treating Refractory Nephrotic Syndrome.

It is acknowledged that even the aforementioned treatments are adopted, not all patients with Refractory Nephrotic Syndrome can be treated effectively. There is still no curative effect in treating Nephrotic Syndrome of some of the pathological types(such as Mesangial Proliferative Glomerulonephritis).

As there is no curative effect, the aforementioned treatments should be stopped(the dose of hormone should be reduced gradually under the guidance of a doctor, and it can not be stopped suddenly when large doses of hormones are adpted.), so as to avoid serious drug side effects.

When the medicines are stopped to use, supporting treatment and symptomatic treatment should be strengthen, and traditional Chinese Medicine can be adopted.

Micro-Chinese Medicine Osmotherapy in our hospital can treat Refractory Nephrotic Syndrome effectively.

And more information about Nephrotic Syndrome

Case of Childhood Nephrotic Syndrome

atient: Zhang Yue, Girl, Three and ten months, Mi Yun County, Beijing.

Treatment history:

On the the middle ten days of August, 2007, the baby suddenly appeared edema in the eyelids without any reasons. For the baby didn’t have any other symptoms, so the parents just ignored it. And a few days later, the edema just faded away by itself.

At the beginning of September, 2007, the baby had obvious edema in the eyelids, faces and the lower limbs. So her parents took her to hospital to have an examination. Urinalysis showed her urine protein is ++++. Biochemistry showed hypoproteinemia, and hyperlipemia. Chest radiograph showed pleural effusion. And the baby also had a cough.

Diagnosis: Primary Nephrotic Syndrome, Myocardial damage and Pneumonia.

She was given some symptomatic treatment and oral hormone. Ten days later, edema and pathological changes of the lungs faded away. And the urine protein became negative when she discharged from the hospital.

11 October, 2010, the reexamination in the Children's Hospital showed the urine protein was +. And according to the doctor, she reduced the intake of the hormone.

30 October, 2010, urine protein was +++, and edema recurred.

31 October, 2010, the parents took Zhang Yue to Shijiazhuang Kidney Disease Hospital to have a further treatment.

The records in Shijiazhuang Kidney Disease Hospital:

Admission complaints: Recurring edema in the eyelids and the body, Urine protein for two months, and a relapse of the disease.

Admission date: October， 2007 ---5 December, 2007

The physical sign and condition when admission: moon-shaped face, slight edema in the eyelids, pitting edema in the lower limbs, obvious distention of the belly, the urine protein+++, occult blood+/—, Urine Protein Quantitation in 24 hours 4.6g/24h, hypoproteinemia, hyperlipemia, high coagulation and viscosity of the blood, and white blood cell increasing.

Diagnosis in Shijiazhuang Kidney Disease Hospital: Primary Nephrotic Syndrome in the stage of inflammatory reaction of the Renal fibrosis.

Treatment: when she was admitted into Shijiazhuang Kidney Disease Hospital, she was given Micro-Chinese Medicine Osmotherapy and western medicines for 35 days to achieve the purpose of dilatation, diuresis, apocatastasis, anticoagulation and antithrombus. On the fifth day, the baby got better with the fading edema. When she was discharged from the hospital, her edema completely disappeared. Mental state was good. Urine Protein Quantitation in 24 hours was 0.3g/24h，total protein was 37.32g/l. White blood cells was 32.34g/l. Hypoproteinemia, hyperlipemia, high coagulation and viscosity of the blood were all got different improvement.

Expert comments: Nephrotic Syndrome is a most seen Childhood Nephropathy. For the treatment, the western medicines often use hormones. The advantage is they can eliminate the large amount of urine protein and edema. The disadvantage is the disease is easy to recur and some side effects may happen. Just like this case, the effect is very good and also quick when the baby girl uses western medicines, but in two months the disease recurs for several times. Every recurrence will accelerate the disease condition and bring difficulty for the following treatment.

This patient was in the inflammatory reaction stage of the kidney fibrosis, in which stage Micro-Chinese Medicine can exert great function. The Micro-Chinese Medicine can control the proceeding of the pathological damages, fibrosis process and the scarring rate of progress. Starting from the disease root, the medicines can repair the damaged kidney functions, gradually improve the kidney functions and effectively eliminate the symptoms of urine protein and edema. The advantages of the Micro-Chinese Medicine Osmotherapy are: for one hand, the medicines are applied to the patients by Osmotherapy, which is by the way of external application, not for oral use, so there will not appear the situation that the children refuse to take medicines and also it can avoid some side effects. For the other hand, it starts from the disease root, and gradually repair the damaged kidney units, so the disease is not easy to recur.

Using Micro-Chinese Medicine to Treat Nephrotic Syndrome

Many patients would like to ask whether Nephrotic Syndrome can be cured. Here we will see how Micro-Chinese medicine treat Nephrotic Syndrome. This therapy is based on traditional Chinese medicine and can make the medicine effect quickly with modern Chinese medicine technology.
Let’s see the advantages of micro-Chinese medicine in treating Nephrotic Syndrome.
1. The concentration of medicine activity has been obviously enhanced. The same amount of medicine has been micronized into nanoscale medicine with strong ultrasonic cavitation technology. The concentration has been increased over 3～4 times. The original molecular structure of the Chinese medicine has been changed and the original physiochemical performance has been strengthened and release highly effective medicine ingredients. At the same time, the original bioactivity of the Chinese medicine has been greatly increased and the efficacy has been given full play.
2. The permeability of the medicine has been significantly enhanced. The fibrous membrane outside the kidneys is composed of dense connective tissue and a little amount of elastic fibers. It has the function of protecting the renal parenchyma. The key problem of traditional medication method is that the medicine cannot break the barrier and much effective medicine has blocked outside this barrier. Micro-Chinese medicine Osmotherapy has taken advantage of the activity of micro particles, it brings the micro-Chinese medicine directly to the kidneys through the skin with the action of the waves and pulse current of the osmoscope. It has improved the medicine supply and efficacy thousands of times and achieved the effect of fast cure and no future trouble. This process needs only two hours.
3. Targeting effect. With the action of osmoscope, micro-Chinese medicine can quickly go through the ‘barrier ‘ and selectively link with the cells. When it is dissolved in the cells, it will release high effective Chinese medicine ingredients and finish the attack to the lesions. It can thoroughly crush and split the immune complex and the damaged tissues such as hyperplastic mesangial cells, matrix and the sclerosed glomeruli. At last it will break them into pieces and expel them out of body through phagocytose or metabolism. This course is slowly and takes generally 3～4 days.
4. The appetency to the lesions. The broken molecular chain of the micronized Chinese medicine has strong coalescence tendency with glomerular basement membrane. The broken molecular chain with positive charge will link with the molecular valence bond of the damaged cells, which promotes the synthetization of the heparan sulfate and the silaoprotein on the basement membrane and restrain its decomposition thus maintaining the barrier function of the negative charge of the basement membrane. Thereby, the protein leakage will be reduced and the discharge of toxins will be increased. It not only repair the basement mechanical barrier and electrical barrier, but also recover the selective filtration function. The average clinical time is about 20 hours.
5. Increase hemoperfusion and blood flow of microcirculation. When entering through the collateral channels in the renal area, the waves and the pulse current increase the local heat significantly, so the speed of blood flow increases, renal arteries are expanded and effective glomerular perfusion increases thus improving the symptoms of high glomerular perfusion, high inside pressure and high filtration, promoting the metabolism, perfecting the repair and speeding up the recovery.
6. Good effect on absorption and reabsorption. After the full combination of the Chinese medicine particles and the lesions, the effective ingredients of the medicine is primarily absorbed, blood flow of renal microcirculation and metabolism is sped up, the medicine consumption is lowered and the medicine effect is given full play. Thereby, the purpose of cure is truly achieved. This process is also slow and can also be called stage of ‘generation change’. The clinical time is about 4—5 days and there are changes every day.

Protein Intake of Nephrotic Syndrome

Patients with Nephrotic Syndrome will lose a great amount of protein through urine. If they don’t supplement enough protein in time, it will cause severe deficiency of protein of the body. Protein is the essential substance to sustain our lives, so if the protein is deficient, it will cause edema, or any other diseases which may even threaten the people’s life. Some rumors say that the kidney disease patients should not eat meat, eggs, alepidote fish etc, it is not scientific. We should formulate the diet depending on the actual condition. For patients with Nephrotic Syndrome, they should have more protein, especially some high-quality protein, such as milk, chicken, lean meat, fish etc. However, they can’t take protein without restrictions. Too much protein will burden the kidneys and aggravate the renal damage.
Then how much protein intake is proper for the patients with Nephrotic Syndrome? We can answer this question from two aspects:
From one hand, if the patient’s renal function is normal, the intake amount of the protein is 1g/d every one kg weight and plus the amount protein lost in the urine.
From the other hand, if the patient has azotemia, (the urea nitrogen and serum creatinine is higher than the normal), they should properly limit the intake of protein. Generally the intake of protein should be better about 40g daily. The kidney disease patients should choose high-quality protein food. An egg contains about 6g protein, a bowl of milk (about 200ml) may contain 6g protein, 50g lean meat contains about 8g protein, and chicken contains more protein than lean meat but less than fish. Therefore, we can estimate the amount of the daily intake of protein for the patients.
We need a certain amount heat to sustain our lives. For those patients with azotemia, who should limit the intake of protein, should have enough carbohydrate, like cane sugar or glucose, vegetables and fruits rich in vitamin.
If the patients have edema, they should also limit the intake of salt. The general intake amount should be less than 3 g daily.