Nowadays, people pay more and more attention to health. As one of the most common disease, Diabetic Nephropathy threatens our life at every moment. So it is necessary for us to learn something about Diabetic Nephropathy to prevent us from developing this disease.
The following are main pathogeny of Diabetic Nephropathy:
I High protein diet: High protein diet will aggravate Diabetic Nephropathy. Diabetic Nephropathy patients shall limit the intake of Carbohydrate strictly, and daily meals should be based on food with high protein and fiber. If we do not follow this, too much protidtemns and phosphorus load will aggravate pathological damages of Diabetic Nephropathy.
II Effect of high blood pressure: many diabetics suffer from hypertension because of lipid metabolic disturbance, atherosclerosis and other reasons. Most of them have microalbuminuria, which is an indicator that kidneys are damaged.
III High blood sugar: long-term and excessive high blood sugar will lead to increase of capillary permeability and exosmosis of plasma protein, and then cause damage of glomerular capillary basement membrane and shrinking of renal tissues.
According to extent of damage, Diabetic Nephropathy can be classified into 5 stages.
Stage I: this stage is characterized by high glomerular filtration rate and large kidneys’ size. Meanwhile, renal blood flow, glomerular capillary perfusion and glomerular internal pressure will also increase.
Stage II: Urinary Albumin Excretion Rate (UAER) is normal in this stage (<20 μg/min or <30 mg/24h). UAER will increase after exercise and drop to normal range after rest.
Stage III: early stage of Diabetic Nephropathy. This stage is characterized by continued higher level of UAER (20～200 μg/min or 30～300 mg/24h), and high GFR maybe one of reasons of sustained microalbuminuria.
Stage IV: this stage is called clinical Diabetic Nephropathy or overt Diabetic Nephropathy, which is characterized by microalbuminuria, high UAER (UAE>200 μg/min) or sustained high urine protein (>0.5 g).
Stage V: stage of renal failure. Various symptoms and complications of renal failure occur, which are main causes of death.
We will know much about our own body conditions if we understand pathogeny of Diabetic Nephropathy. Meanwhile, Patients with Diabetes should also care about their diet and keep doing physical exercise. Some simple and effective methods are necessary to follow to fight against Diabetic Nephropathy.
没有评论:
发表评论